HuagongsheHuagongshe Chemistry Print Report · For research reference only
alpha Lipoic acid → 5-[1,2]Dithiolan-3-yl-pentanoic acid [4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | alpha Lipoic acid | HCID 864 | — |
| Reactant | 4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine | HCID 11557499 | — |
| Product | 5-[1,2]Dithiolan-3-yl-pentanoic acid [4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-amide | HCID 58820318 | 51% |
Reaction Steps
Pet-151 was prepared according to the general procedure described hereinabove and the procedure described above for the preparation of Pet-154, using 5-[1,2]Dithiolan-3-yl-pentanoic acid (DL-Lipoic acid) and 4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine (Pet-10) as the starting materials, in an overall yield of 51% as a pale yellow liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968575B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-f6893485dc5c4415b0acfcf776cb13da |
| Source note | uspto-grants-2011_06 |