反应详情

To a 28% sodium methoxide/methanol solution (4.24 g) in methanol (35 mL) was added methyl 2-(bromomethyl)acrylate (1.79 g) in methanol (10 mL). The mixture was stirred at room temperature for 2 hours and was heated to reflux for 3 hours. The reaction mixture was poured into 2N hydrochloric acid-ice, then extracted with ethyl acetate. The obtained organic layer was washed with brine, dried and concentrated to give the title compound (1.33 g) having the following physical data.

1. temperaturewas heated
2. temperatureto reflux for 3 hours
3. extractionextracted with ethyl acetate
4. washThe obtained organic layer was washed with brine
5. customdried
6. concentrationconcentrated