Dimethylformamide → HCID 67255853, compound

Participants

Reaction Conditions

Reaction Steps

To a mixed solution of the compound prepared in Example 45 (413 mg) in acetic acid (7.6 mL)-N,N-dimethylformamide (7.0 mL) was added ammonium acetate (1.18 g) and the mixture was stirred at 100° C. for an hour. The reaction mixture was poured into 5N aqueous solution of sodium hydroxide and the mixture was extracted with ethyl acetate. After having made the water layer acidity with 2N hydrochloric acid, the mixture was extracted with ethyl acetate. The organic layer was put together, washed with brine, dried and concentrated. The obtained residue was purified by preparative medium pressure liquid chromatography W-prep 2XY (column: main column L, inject column M; automatic condition setting: hexane:ethyl acetate=1:1, Rf=0.30, preparative isolation mode GR) to give the title compound having the following physical data.

Provenance & Evidence