Water → HCID 67254874, compound

Participants

Reaction Steps

To a solution of 2,6-difluoroaniline (3.2 mL) in N,N-dimethylformamide (20 mL) was added methyl succinyl chloride (3.7 mL) at room temperature and the mixture was stirred for an hour. To the reaction mixture was added water and the mixture was extracted with ethyl acetate. The obtained organic layer was dried and concentrated. The obtained residue was purified by column chromatography on silica gel (hexane:ethyl acetate=7:3→3:2) to give the title compound (1.7 g) having the following physical data.

Provenance & Evidence