Benzyl Bromide → HCID 67255511, compound

Participants

Reaction Steps

To a solution of the compound prepared in Example 180 (5.9 g) in N,N-dimethylformamide (hereinafter abbreviated to DMF) (120 mL) were added benzyl bromide (4.3 mL) and potassium carbonate (9.9 g) and the reaction mixture was stirred at room temperature for 12 hours. The reaction mixture was filtered through Celite (trade name) and concentrated in vacuum condition to remove DMF. To the obtained residue was added water and the organic layer was extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate and concentrated in vacuum condition. The obtained residue was purified by column chromatography on silica gel (hexane:ethyl acetate=6:1→4:1) to give the title compound (6.1 g) having the following physical data.

Provenance & Evidence