Agn-PC-0nddf9 → (E)-3-(3-(2-(2,6,6-Trimethylcyclohex-1-enyl)vinyl)phenyl)propan-1-amine

HRID 242701Notes

Reaction equation

HRID 242701 reaction equation
[Br-].C1([P+](C2C=CC=CC=2)(C2C=CC=CC=2)[CH2:9][C:10]2[C:15]([CH3:17])([CH3:16])[CH2:14][CH2:13][CH2:12][C:11]=2[CH3:18])C=CC=CC=1.O=C1C2C(=CC=CC=2)C(=O)[N:33]1[CH2:42][CH2:43][CH2:44][C:45]1[CH:46]=[C:47]([CH:50]=[CH:51][CH:52]=1)[CH:48]=O>>[CH3:18][C:11]1[CH2:12][CH2:13][CH2:14][C:15]([CH3:16])([CH3:17])[C:10]=1/[CH:9]=[CH:48]/[C:47]1[CH:46]=[C:45]([CH2:44][CH2:43][CH2:42][NH2:33])[CH:52]=[CH:51][CH:50]=1

Participants

3

Reactant 2

HCID 10950920Agn-PC-0nddf9HCID 577664653-(3-(1,3-Dioxoisoindolin-2-yl)propyl)benzaldehyde

Product 1

HCID 25101342(E)-3-(3-(2-(2,6,6-Trimethylcyclohex-1-enyl)vinyl)phenyl)propan-1-amine

Procedure

(E)-3-(3-(2-(2,6,6-Trimethylcyclohex-1-enyl)vinyl)phenyl)propan-1-amine was prepared by coupling triphenyl((2,6,6-trimethylcyclohex-1-enyl)methyl)phosphonium bromide (24) (Scheme 8) with 3-(3-(1,3-dioxoisoindolin-2-yl)propyl)benzaldehyde (29) (Scheme 9).

Sources & evidence

ORD record
ord-b13861df66ec41f688ba4b8565a02ec6
Source dataset
uspto-grants-2014_02
Patent number
US08653142B2

Reaction notes

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