Water → 4-(2-Hydroxyacetyl)benzonitrile

HRID 2427141Notes

Reaction equation

HRID 2427141 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4].[OH2:13]>C(#N)C>[OH:13][CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[CH:7][CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 962WaterHCID 986544-(Bromoacetyl)benzonitrile

Product 1

HCID 179928864-(2-Hydroxyacetyl)benzonitrile

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 1 g of 4-(2-bromoacetyl)benzonitrile in acetonitrile (5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min) The same experiment is conducted five times. All the vials are collected, extracted with ethyl ether, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Workup

  1. customAll the vials are collected
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-fc19a66bb1db4d53855eabf0420fa6a8
Source dataset
uspto-grants-2011_06
Patent number
US07968581B2

Reaction notes

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