HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allyl bromide → 4-[2-(2-Propenyloxy)acetyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allyl bromide | HCID 7841 | — |
| Reactant | Calcium Sulfate | HCID 24497 | — |
| Reactant | 4-(2-Hydroxyacetyl)benzonitrile | HCID 17992886 | — |
| Catalyst | Silver(II) oxide | HCID 92152 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-[2-(2-Propenyloxy)acetyl]benzonitrile | HCID 62029859 | — |
Reaction Steps
To a solution of 2.7 g of 4-(2-hydroxyacetyl)benzonitrile in allyl bromide (15 mL) is added 10.2 g calcium sulfate and 6.7 g of silver oxide. The mixture is stirred under argon and in the dark for 2 hours. The mixture is diluted with AcOEt, filtered on celite, concentrated and purified on silica gel (ethyl acetate/cyclohexane: 0/100 to 50/50) to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968581B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-9f71bd9a2dac498ca4cbdc8ecc20e832 |
| Source note | uspto-grants-2011_06 |