Water → 3-(2-Hydroxyacetyl)benzonitrile

HRID 2427147Notes

Reaction equation

HRID 2427147 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])=[O:4].[OH2:13]>C(#N)C>[OH:13][CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][CH:12]=1)[C:8]#[N:9])=[O:4]

Participants

4

Reactant 2

HCID 962WaterHCID 27358673-(2-Bromoacetyl)benzonitrile

Product 1

HCID 184047733-(2-Hydroxyacetyl)benzonitrile

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 776 mg of 3-(2-bromoacetyl)benzonitrile in acetonitrile (5 mL) and water (10 mL) is treated under microwave irradiation (125° C., 50 min) The same experiment is realized a second time with 976 mg. All the vials are collected, extracted with ethyl ether, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Workup

  1. customAll the vials are collected
  2. extractionextracted with ethyl ether
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-cf3cc6f3e75546cb957bc0c7f0907401
Source dataset
uspto-grants-2011_06
Patent number
US07968581B2

Reaction notes

Loading…