反应详情

328 μL of trifluoroborane-dimethylsulfide complex are added to a solution of 354 mg of 4-[4-(3-cyanophenyl)-2,5-dioxo-3-methyl-4-[(2-propenyloxy)methyl]imidazolidin-1-yl]-2-trifluoromethylbenzonitrile (in DCM (5 mL. The mixture is stirred 6 hours at room temperature, diluted with DCM, washed with an aqueous solution of sodium bicarbonate, dried over magnesium sulfate, concentrated and purified on silica gel (ethyl acetate/cyclohexane 0/100 to 50/50) to give the desired compound.

1. washwashed with an aqueous solution of sodium bicarbonate
2. dry with materialdried over magnesium sulfate
3. concentrationconcentrated
4. custompurified on silica gel (ethyl acetate/cyclohexane 0/100 to 50/50)