Water → 2-Hydroxy-1-(3-methylphenyl)ethan-1-one

HRID 2427158Notes

Reaction equation

HRID 2427158 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4].[OH2:12]>C(#N)C>[OH:12][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 962WaterHCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

Product 1

HCID 183729052-Hydroxy-1-(3-methylphenyl)ethan-1-one

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 2-bromo-1-(3-methylphenyl)ethanone (1 g) in acetonitrile (2.5 mL) and water (13 mL) is treated under microwave irradiation (125° C., 50 min) The same experiment is repeated three times. All the vials are collected, extracted with DCM, dried over magnesium sulfate and concentrated under vacuum to give the desired compound.

Workup

  1. customAll the vials are collected
  2. extractionextracted with DCM
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-7d6e99c9ecd446f09f0ddbbdda7b6a8b
Source dataset
uspto-grants-2011_06
Patent number
US07968581B2

Reaction notes

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