1-Methylpiperazine → tert-Butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate

Participants

Reaction Steps

A solution of 4-fluoro-2-nitro-benzoic acid tert-butyl ester (13 g, 54 mmol) and N-methyl-piperazine (17 mL) was stirred at room temperature for about 6 hours. The reaction mixture was then diluted with water (800 mL) and maintained under magnetic stirring for about 20 hours. The resulting solid was filtered, washed thoroughly with water and dried under vacuum at 40° C. The title compound was obtained as a yellow solid (16.4 g, 94% yield), and was used in the next step without any further purification.

Provenance & Evidence