反应详情

温度

75 °C

Dissolve [(S)-4-(2-amino-pyridin-3-ylmethyl)-7-cyano-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl]-carbamic acid isopropyl ester (253 mg, 0.650 mmol) in EtOH (25 mL). Add 3 Å molecular sieves and glyoxylic acid monohydrate (239 mg, 2.60 mmol), then stir at 40-110° C. for 18 h under hydrogen (60 psi, 4.08 bar). Filter the reaction through a pad of diatomaceous earth and wash the catalyst/sieves with THF (50 mL). Combine the filtrate and concentrate in vacuo to a yellow oil. Triturate with water (30 mL) and sonicate the resulting aqueous slurry for 5 min. Filter off a tan solid and dry in vacuo. Triturate the solid with Et2O (5 mL) and sonicate the slurry for 30 min. Filter to obtain 190 mg (65%) of the product as a tan solid. LCMS 100% @ 3.99 min m/z 448 (M+H), 446 (M−H).

1. filtrationFilter
2. customthe reaction through a pad of diatomaceous earth
3. washwash the catalyst/sieves with THF (50 mL)
4. concentrationCombine the filtrate and concentrate in vacuo to a yellow oil
5. customTriturate with water (30 mL)
6. customsonicate the resulting aqueous slurry for 5 min
7. filtrationFilter off a tan solid
8. customdry in vacuo
9. customTriturate the solid with Et2O (5 mL)
10. customsonicate the slurry for 30 min
11. filtrationFilter