Sodium Azide → HCID 86632159, compound

HRID 242729Notes

Reaction equation

Cl[CH2:2][C@@H:3]([OH:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7](/[CH:11]=[CH:12]/[C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:20])[CH:6]=1.[N-:22]=[N+:23]=[N-:24].[Na+]>>[N:22]([CH2:2][C@@H:3]([OH:21])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7](/[CH:11]=[CH:12]/[C:13]2[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:20])[CH:6]=1)=[N+:23]=[N-:24]

Participants

Reactant 2

HCID 33557Sodium Azide

HCID 68941035HCID 68941035, compound

Product 1

HCID 86632159HCID 86632159, compound

Procedure

(S,E)-1-Chloro-3-(3-(2,6-dichlorostyryl)phenyl)propan-2-ol was reacted with NaN3 following the method used in Example 74 to give (S,E)-1-azido-3-(3-(2,6-dichlorostyryl)phenyl)propan-2-ol. This material was used in the next synthetic step without purification.

Sources & evidence

ORD record: ord-56ce268e498b4b1f9f75ba1f568ea9ce
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08653142B2

Reaction notes

Loading…