反应详情

Heat a solution of 5-bromo-1,3-dichloro-2-methylbenzene (97 mg, 0.40 mmol), N-bromosuccinimide (76 mg, 0.425 mmol) and benzoyl peroxide (16 mg, 0.06 mmol) in CCl4 (5 mL) to reflux for 3 hours under N2. Cool the reaction to room temperature and concentrate to an orange residue. Purify the residue by silica gel chromatography eluting with hexanes to afford 112 mg (87%) of the product as white crystals.

1. temperatureto reflux for 3 hours under N2
2. temperatureCool
3. customthe reaction to room temperature
4. concentrationconcentrate to an orange residue
5. customPurify the residue by silica gel chromatography
6. washeluting with hexanes