反应详情

4-Fluoro-2-methyl-benzoic acid methyl ester (600 mg, 3.6 mmol), N-bromosuccinimide (635 mg, 3.6 mmol) and benzoyl peroxide (43 mg, 1.79 mmol) in CCl4 (15 mL) was stirred at 90° C. for 3 hours. The reaction was cooled to room temperature, filtered, washed with CCl4 and the solvent was removed under reduced pressure to provide a white solid. 1H NMR (300 MHz, CDCl3): δ 8.01 (d, 1H), 6.99 (d, 1H), 6.88 (dd, 1H), 4.98 (s, 2H), 3.93 (s, 3H), 3.89 (s, 3H).

1. filtrationfiltered
2. washwashed with CCl4
3. customthe solvent was removed under reduced pressure
4. customto provide a white solid