HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 5-bromo-2,3-dihydro-1H-isoindol-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Methyl 4-bromo-2-(bromomethyl)benzoate | HCID 22031079 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-bromo-2,3-dihydro-1H-isoindol-1-one | HCID 22607119 | 90% |
Reaction Steps
4-Bromo-2-bromomethyl-benzoic acid methyl ester (3.70 g) was suspended in 2M NH3 in MeOH (36 mL) and concentrated ammonium hydroxide (12 mL) for eighteen hours. The solid product was filtered to provide the title compound as a colourless solid (2.30 g, 90%). 1H NMR (300M, CDCl3): δ 7.68 (m, 3H), 4.44 (s, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07968570B2 |
| Source dataset | uspto-grants-2011_06 |
| ORD ID | ord-08af4fdb718842e0b5846b20d14aa1ea |
| Source note | uspto-grants-2011_06 |