(Dimethyl sulfide)trihydroboron → HCID 68940604, compound

HRID 242751Notes

Reaction equation

HRID 242751 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]([OH:13])[CH2:10][C:11]#[N:12])[CH:5]=[C:6]([CH3:8])[CH:7]=1.CSC.B>>[NH2:12][CH2:11][CH2:10][CH:9]([C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([Br:1])[CH:3]=1)[OH:13]

Participants

3

Reactant 2

HCID 12423031(Dimethyl sulfide)trihydroboronHCID 68943348HCID 68943348, compound

Product 1

HCID 68940604HCID 68940604, compound

Procedure

Reduction of 3-(3-bromo-5-methylphenyl)-3-hydroxypropanenitrile using borane methyl sulfide following the method used in Example 79 gave 3-amino-1-(3-bromo-5-methylphenyl)propan-1-ol which was used directly in the next step.

Sources & evidence

ORD record
ord-704399a951934500ac20caf5ecff79c0
Source dataset
uspto-grants-2014_02
Patent number
US08653142B2

Reaction notes

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