Triethylamine → HCID 57949692, compound

Participants

Reaction Conditions

Reaction Steps

5-(5-Hydroxymethyl-pyridin-3-yl)-7-methyl-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one (72 mg, 0.168) was diluted with dichloromethane (5 mL) and the solution was cooled to 0° C. in an icebath. Triethyl amine (47 μL, 0.168 mmol) and methanesulfonyl chloride (19 μL, 0.252 mmol) were added and stirring continued for 1 hr at 0° C. The mixture was quenched with cold saturated sodium bicarbonate and the organics were dried over anhydrous sodium sulfate, filtered and concentrated to afford the title compound as black oil (70 mg, 100%). 1H NMR (300 MHz, CDCl3): δ 8.01 (s, 1H), 7.43-7.37 (m, 5H), 7.23-7.20 (m, 3H), 5.37 (s, 2H), 4.83 (s, 2H), 4.34 (s, 2H), 3.09 (s, 3H), 2.86 (s, 3H).

Provenance & Evidence