2,4-Difluoro-1-iodobenzene → HCID 57949494, compound

Participants

Reaction Steps

2-Prop-2-ynyl-2,3-dihydro-isoindol-1-one (50.0 mg, 0.29 mmol) was dissolved in triethylamine (2 mL). To this was added Pd(PPh3)4 (13 mg, 0.012 mmol), CuI (6.7 mg, 0.035 mmol) and 2,4-difluoro-1-iodo-benzene (52.0 μL, 0.438 mmol) and the reaction was allowed to stir overnight. The solvent was evaporated and the residue was purified by prep. TLC (30% EtOAc/Hexanes) to afford the title compound (20.0 mg, 24%) as a brown oil. 1H NMR (300 MHz, CDCl3): δ 7.90 (d, 1H), 7.45 (m, 4H), 6.84 (t, 2H), 4.72 (s, 2H), 4.59 (s, 2H).

Provenance & Evidence