HCID 57949494, compound → HCID 57949708, compound

HRID 2427531Notes

Reaction equation

HRID 2427531 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]#[C:10][CH2:11][N:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:21].[H][H]>CCO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][N:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:21]

Participants

5

Reactant 2

HCID 57949494HCID 57949494, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57949708HCID 57949708, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-[3-(2,4-Difluoro-phenyl)-prop-2-ynyl]-2,3-dihydro-isoindol-1-one was dissolved in EtOH (5 mL) and a small amount of 10% Pd/C was added. A hydrogen balloon was attached to the flask and the system was evacuated and flushed three times. The reaction was allowed to stir for twenty-two hours. The reaction mixture was filtered and concentrated to provide the title compound as a colourless oil (13.0 mg).

Workup

  1. customthe system was evacuated
  2. customflushed three times
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-f853923d3bdc45b497c71794af7cb8c4
Source dataset
uspto-grants-2011_06
Patent number
US07968570B2

Reaction notes

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