Phthalimidine → HCID 57949578, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,3-dihydro-isoindol-1-one (0.133 g, 1 mmol,), 1-bromomethyl-4-chloro-benzene (0.246 g, 1.2 mmol), Cs2CO3 (0.816 g, 2.5 mmol), and 18-crown-6 (0.026 g, 0.1 mmol) in acetone (5 mL) was stirred at 70° C. for 16 h. Workup and silica gel column chromatography using 30% ethyl acetate in hexane afforded 2-(4-chloro-benzyl)-2,3-dihydro-isoindol-1-one (0.125 g, 97%). 1H NMR (300 MHz, CDCl3): δ (ppm) 4.24 (s, 2H), 4.76 (s, 2H), 7.22-7.54 (m, 7H), 7.90 (d, 1H).

Provenance & Evidence