Phthalimidine → HCID 57949650, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,3-dihydroisoindol-1-one (0.066 g, 0.5 mmol,), 2-(bromoethoxy)benzene (0.121 g, 0.6 mmol), Cs2CO3 (0.408 g, 1.25 mmol), and 18-crown-6 (0.013 g, 0.05 mmol) in acetone (3 mL) was stirred at 70° C. for 16 h. Workup and silica gel column chromatography using 30% ethyl acetate in hexane afforded 2-(2-phenoxy-ethyl)-2,3-dihydro-isoindol-1-one (0.099 g, 78%). 1H NMR (300 MHz, CDCl3): δ (ppm) 4.05 (t, 2H), 4.26 (t, 2H), 4.64 (s, 2H), 6.92 (m, 3H), 7.22-7.60 (m, 5H), 7.88 (d, 1H), GC-MS: m/z 253 (M)+.

Provenance & Evidence