関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 2-(bromomethyl)benzoate | HCID 2734813 | — |
| 反応物 | 3-(2-Chlorophenyl)propan-1-amine | HCID 5200411 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 2-[3-(2-Chloro-phenyl)-propyl]-2,3-dihydro-isoindol-1-one | HCID 57949485 | 53.2% |
反応手順
A mixture of 2-bromomethyl-benzoic acid methyl ester (0.115 g, 0.5 mmol), 3-(2-chloro-phenyl)-propylamine (0.102 g, 0.6 mmol), and K2CO3 (0.207 g, 1.5 mmol) in toluene (3 mL) was heated with stirring at 100° C. for 2 h. Workup and silica gel column chromatography using 30% ethyl acetate in hexane afforded 2-[3-(2-chloro-phenyl)-propyl]-2,3-dihydro-isoindol-1-one (0.076 g, 51%). 1H NMR (300 MHz, CDCl3): δ (ppm) 1.99 (m, 2H), 2.79 (t, 2H), 3.69 (t, 2H), 4.41 (s, 2H), 7.14-7.58 (m, 7H), 7.88 (d, 1H). GC-MS: m/z 285 (M)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07968570B2 |
|---|
| 出典データセット | uspto-grants-2011_06 |
|---|
| ORD ID | ord-1df23dae3caa47be968028c3a305f6bd |
|---|
| 出典メモ | uspto-grants-2011_06 |
|---|
