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7-Chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one → (S)-7-Chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one | HCID 57949799 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | (S)-7-Chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one | HCID 57949417 | — |
| 生成物 | (R)-7-Chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one | HCID 57949812 | — |
反応手順
Chromatography (HPLC) of racemic mixture of 7-chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one (1.2 g) through ChrialCel OD (250×20 mm i.d., 10 μm)] using 5% isopropyl alcohol in hexanes as an eluent afforded (S)-7-Chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one (0.044 g) and (R)-7-Chloro-2-[1-(4-chloro-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one (0.058 g)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07968570B2 |
| 出典データセット | uspto-grants-2011_06 |
| ORD ID | ord-879f3e632f3c482dbb82ce9359922eba |
| 出典メモ | uspto-grants-2011_06 |