Ethyl Acetate → HCID 57949766, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromomethyl-6-chloro-benzoic acid methyl ester (0.132 g, 0.5 mmol,), 4-methyl benzylamine (0.102 mL, 0.8 mmol), and K2CO3 (0.276 g, 2.0 mmol) in toluene (5 mL) was heated with stirring at 100° C. for 2 h. Workup and silica gel column chromatography using 30% ethyl acetate in hexane afforded 7-chloro-2-(4-methyl-benzyl) 2,3-dihydro-isoindol-1-one (0.06 g, 34%). 1H NMR (300 MHz, CDCl3): δ (ppm) 4.22 (s, 2H), 4.78 (s, 2H), 7.12-7.46 (m, 7H). GC-MS: m/z 271 (M)+.

Provenance & Evidence