Cesium carbonate → HCID 86672917, compound

Participants

Reaction Steps

Compound I, that is, bis[2-(trimethylsilyl)ethyl] phosphonate (582 mg, 2.05 mmol) is dissolved in dimethylformamide (“DMF”) (25 ml) to manufacture a solution III-1. Cesium carbonate (Cs2CO3)) (2 g, 6.13 mmol) and tetrabutylammonium iodide (“TBAI”) (2.26 g, 6.13 mmol) are added to the solution III-1, and stirred at room temperature for approximately 1 hour under a nitrogen atmosphere to manufacture a solution III-2. After approximately 1 hour, compound II, that is, 1-[1-(4-chloromethylphenyl)ethoxy]-2,2,6,6-tetramethyl-piperidine (1.9 g, 6.13 mmol), is added to the solution III-2, and stirred for approximately 24 hours to manufacture a suspension III-3. The suspension III-3 is purified with ethyl acetate (“EtOAc”), washed with distilled water, dried over anhydrous magnesium sulfate (MgSO4), and then condensed under a vacuum to obtain non-purified {4-[1-(2,2,6,6-tetramethyl-piperidine-1-yloxy)-ethyl]-benzyl}-phosphonic acid bis-(2-trimethylsilylethyl) ester.

Provenance & Evidence