Ethyl Acetate → HCID 67252468, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-2-bromomethyl-6-iodo-benzoic acid methyl ester (0.389 g, 1.0 mmol), 4-fluoro-benzylamine (0.137 mL, 1.2 mmol), and K2CO3 (0.276 g, 2.0 mmol) in toluene (5 mL) was heated with stirring at 100° C. for 2 h. Workup and silica gel column chromatography of the product using 30% ethyl acetate in hexane afforded 5-chloro-7-iodo-2-(4-fluoro-benzyl)-2,3-dihydro-isoindol-1-one (0.149 g, 37%). 1H NMR (300 MHz, CDCl3): δ (ppm) 4.15 (s, 2H), 4.75 (s, 2H) 7.02 (t, 2H), 7.27 (t, 2H), 7.36 (s, 1H), 7.92 (s, 1H). GC-MS: m/z 401 (M)+.

Provenance & Evidence