Chloroform methanol → HCID 11569003, compound

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A mixture of 7-methyl-5-[3-(4-methyl-piperazin-1-yl)-prop-1-ynyl)-2-(4-phenoxy-benzyl)-2,3-dihydro-isoindol-1-one (0.056 g, 0.11 mmol) and 10% palladium-carbon (0.015 g) in ethanol (25 mL) was reduced under 45 p.s.i. hydrogen. Workup and silica gel column chromatography using 5:1 CHCl3-MeOH afforded 7-Methyl-5-[3-(4-methyl-piperazin-1-yl)-propyl]-2-(4-phenoxy-benzyl)-2,3-dihydro-isoindol-1-one (0.056 g, 100%). 1H NMR (300 MHz, CDCl3): δ (ppm) 1.79 (m, 2H), 2.23-2.66 (m, 18H), 4.18 (s, 2H), 4.72 (s, 2H), 6.88-7.38 (m, 11H).

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