1-Methylpiperazine → HCID 57949448, compound

Participants

Reaction Steps

A mixture of 5-bromo-2-[2-(4-phenoxy-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one (0.128 g, 0.31 mmol), 1-methyl piperazine (0.046 mL, 0.41 mmol), Pd2.dba3 (0.009 g, 0.01 mmol), BINAP (0.012 g, 0.02 mmol), and sodium tertiary-butoxide (0.048 g, 0.5 mmol) in toluene (3 mL) was heated to reflux for 3 h. Workup and silica gel column chromatography using 30% ethyl acetate in hexane afforded 5-(4-Methyl-piperazin-1-yl)-2-[2-(4-phenoxy-phenyl)-ethyl]-2,3-dihydro-isoindol-1-one (0.039 g, 29%). 1H NMR (300 MHz, CDCl3): δ (ppm) 2.36 (s, 3H), 2.58 (m, 4H), 2.94 (t, 2H), 3.32 (m, 4H), 3.81 (t, 2H), 4.16 (s, 2H), 6.82-7.35 (m, 1H), 7.69 (d, 1H).

Provenance & Evidence