2-(Dimethylamino)ethanol → HCID 57949738, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-7-trifluoromethyl-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one (0.123 g, 0.3 mmol), 2-dimethylamino-ethanol (0.05 mL, 0.5 mmol), Pd(OAc)2 (0.002 g, 0.006 mmol), and Cs2CO3 (0.195 g, 0.6 mmol) in toluene (3 mL) was stirred at 100° C. for 24 h. Workup and silica gel column chromatography using 5:1 CHCl3-MeOH afforded 5-(2-dimethylamino-ethoxy)-2-(4-trifluoromethoxy-benzyl)-7-trifluoromethyl-2,3-dihydro-isoindol-1-one (0.050 g, 36%). 1H NMR (300 MHz, CDCl3): δ (ppm) 2.35 (s, 6H), 2.73 (t, 2H), 4.13 (t, 2H), 4.23 (s, 2H), 4.74 (s, 2H), 7.04-7.38 (m, 6H).

Provenance & Evidence