反应详情

A solution of 7-chloro-2-(4-trifluoromethoxy-benzyl)-5-trimethylsilanylethynyl-2,3-dihydro-isoindol-1-one (0.100 g, 0.22 mmol) in THF (1 mL) was treated with a 1M solution of tertiary-butyl amino fluoride-THF (1 mL). The reaction mixture was stirred at ambient temperature for 2 h. After this time, GC-MS indicated that the reaction was completed. The reaction solution was poured into water (7 mL) and extracted with diethyl ether (2×20 mL). The combined organic extracts were dried over anhydrous MgSO4, filtered and concentrated to afford 7-chloro-5-ethynyl-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-isoindol-1-one. The material was used without purification.

1. extractionextracted with diethyl ether (2×20 mL)
2. dry with materialThe combined organic extracts were dried over anhydrous MgSO4
3. filtrationfiltered
4. concentrationconcentrated