HCID 57949399, compound → HCID 57949598, compound

Participants

Reaction Steps

4- {[7-Chloro-1-oxo-2-(4-trifluoromethoxy-benzyl)-2,3-dihydro-1H-isoindol-5-ylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester (47 mg, 0.0848 mmol) was stirred in formic acid (4 mL) overnight at room temperature and the solvent was removed under vacuum. The resulting residue was triturated with ether to provide the title compound (29 mg, 74%) as a colorless solid. 1H NMR (300 MHz, CDCl3): δ 8.44 (s, 2H), 7.59 (s, 1H), 7.53 (s, 1H), 7.46 (d, 2H), 7.29 (d, 2H), 4.84 (s, 2H), 4.41 (s, 2H), 4.08 (s, 2H), 3.43-3.39 (m, 2H), 3.03-2.94 (m, 2H), 2.77 (d, 2H), 2.05-2.00 (m, 2H), 1.46-1.42 (m, 2H).

Provenance & Evidence