Potassium Hydroxide → HCID 67148004, compound

HRID 2427785Notes

Reaction equation

HRID 2427785 reaction equation
[Br:1][C:2]1[C:3](=[O:17])[N:4]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([F:16])[CH:10]=2)[N:5]=[CH:6][C:7]=1Br.[OH-:18].[K+]>C(O)C.O>[Br:1][C:2]1[C:3](=[O:17])[N:4]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([F:16])[CH:10]=2)[N:5]=[CH:6][C:7]=1[OH:18]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 54596389HCID 54596389, compound

Product 1

HCID 67148004HCID 67148004, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

4,5-Dibromo-2-(3,5-difluorophenyl)pyridazin-3-one (1.5 g, 0.0041 moles) was suspended in ethanol (50 ml) and potassium hydroxide (0.8 g, 0.0123 moles) was added in water (8 ml). Refluxed for 4 hours with stirring. Evaporated to a low bulk and diluted with water. Acidified to pH2 with conc. hydrochloric acid and extracted with ethyl acetate. Washed with water and dried with anhydrous magnesium sulphate. Filtered and evaporated the filtrate to give an orange solid. Triturated with diethyl ether and dried in a desiccator to give the product as a cream solid. (0.7 g, 56%)

Workup

  1. temperatureRefluxed for 4 hours
  2. customEvaporated to a low bulk
  3. additiondiluted with water
  4. extractionextracted with ethyl acetate
  5. washWashed with water
  6. dry with materialdried with anhydrous magnesium sulphate
  7. filtrationFiltered
  8. customevaporated the filtrate
  9. customto give an orange solid
  10. customTriturated with diethyl ether
  11. customdried in a desiccator

Sources & evidence

ORD record
ord-9228a8b19fc64cd796ed91a042402d96
Source dataset
uspto-grants-2011_06
Patent number
US07968711B2

Reaction notes

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