Triphenylphosphine → HCID 68157796, compound

Participants

Reaction Steps

To a stirred solution of (1-phenyl-1H-benzoimidazol-2-yl)methanol (240 mg, 1.02 mmol) and triphenylphospine (295 mg, 1.12 mmol) in DCM (10 mL) was added NBS (200 mg, 1.12 mmol) and the mixture was stirred at RT for 3 h. Volatiles were evaporated under reduced pressure and the residue was purified by column chromatography (Si—PCC, gradient 0-5% MeOH in DCM) affording 2-Bromomethyl-1-phenyl-1H-benzoimidazole as a colourless oil (0.636 g, quantitative yield). LCMS: RT 3.31 min [M+H]+ 386.8/388.8

Provenance & Evidence