Sodium Lauryl Sulfate → HCID 86622595, compound

HRID 2427819Notes

Reaction equation

HRID 2427819 reaction equation
[NH2:1][C:2]1[C:15]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[SH:16].[CH2:17](OS([O-])(=O)=O)CCCCCCCCCCC.[Na+].C(OC=O)=O>O>[S:16]1[C:3]2[CH:4]=[CH:5][C:6]3[C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=4[CH:13]=[CH:14][C:15]=3[C:2]=2[N:1]=[CH:17]1

Participants

5

Reactant 3

HCID 3423265Sodium Lauryl SulfateHCID 9548680Formic anhydrideHCID 86622596HCID 86622596, compound

Product 1

HCID 86622595HCID 86622595, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 mmol of 1-amino phenanthren-2-thiol was added to 20 mL of water, and 20 mg of sodium dodecylsulfate was added while agitating to obtain a uniform mixture. 7.5 mmol of formic anhydride was added for 5 minutes. A precipitation product was obtained in 5-10 minutes. The precipitation product was filtrated and rinsed with 1 ml of water twice followed by drying under vacuum. A non-precipitated reaction mixture was extracted with 25 ml of ethyl acetate twice. The separated organic layer was dried with anhydrous sodium sulfate, and a solvent was removed using a rotatary evaporator under a reduced pressure to obtain phenanthrothiazole at a yield of 69%.

Workup

  1. additionwas added
  2. customto obtain a uniform mixture
  3. customA precipitation product was obtained in 5-10 minutes
  4. filtrationThe precipitation product was filtrated
  5. washrinsed with 1 ml of water
  6. customby drying under vacuum
  7. extractionA non-precipitated reaction mixture was extracted with 25 ml of ethyl acetate twice
  8. dry with materialThe separated organic layer was dried with anhydrous sodium sulfate
  9. customa solvent was removed
  10. customa rotatary evaporator under a reduced pressure

Sources & evidence

ORD record
ord-7b3e0a25916449728ec6d5e06e1441a4
Source dataset
uspto-grants-2011_06
Patent number
US07968715B2

Reaction notes

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