HCID 68157732, compound → HCID 68157390, compound

Participants

Reaction Steps

To a nitrogen purged solution of 4-[2-((S)-1-benzyloxycarbonylaminoethyl)benzoimidazol-1-yl]piperidine-1-carboxylic acid tertbutyl ester (308 mg, 0.644 mmol) in IMS (10 mL) was added 10% Pd/C (32 mg) and the reaction mixture was stirred at RT under a hydrogen atmosphere for 2 h. Additional quantities of 10% Pd/C were subsequently added (41 mg after 2 h and 33 mg after 4 h) and the reaction mixture was stirred at RT under a hydrogen atmosphere for 17 h. The suspension was filtered through a PTFE frit and washed with additional IMS. The filtrate was concentrated in vacuo affording 4-[2-((S)-1-Aminoethyl)benzoimidazol-1-yl]piperidine-1-carboxylic acid tertbutyl ester as a pale yellow oil (202 mg). LCMS: RT 2.34 min [M+H]+ 345.2

Provenance & Evidence