Fructosamine → LX-2932

HRID 2427845Notes

Reaction equation

HRID 2427845 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]#[N:7])=[N:2]1.[CH2:8]1[O:13][C@:12](O)([CH2:14][NH2:15])[C@@H:11]([OH:17])[C@H:10]([OH:18])[C@@H:9]1[OH:19]>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[NH:7][C:12]([C@@H:11]([OH:17])[C@H:10]([OH:18])[C@H:9]([OH:19])[CH2:8][OH:13])=[CH:14][N:15]=2)=[N:2]1

Participants

3

Reactant 2

HCID 20484FructosamineHCID 226246101,2-Oxazole-3-carbonitrile

Product 1

HCID 135912123LX-2932

Procedure

which comprises: combining isoxazole-3-carbonitrile with a solvent and a first base to provide a first reaction mixture; combining the first reaction mixture with fructosamine to provide a second reaction mixture; and isolating (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-5-yl)butane-1,2,3,4-tetraol from the second reaction mixture.

Workup

  1. customa first base to provide a first reaction mixture
  2. customto provide a second reaction mixture

Sources & evidence

ORD record
ord-e49bc778102945109c21a8d6f9886b7a
Source dataset
uspto-grants-2011_06
Patent number
US07968726B2

Reaction notes

Loading…