Sodium Chloride → 4-Methoxy-8-nitro-dibenzo[b,d]furan-1-carboxylic acid

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Reaction Steps

4-Methoxy-8-nitro-dibenzofuran-1-carbaldehyde (1.03 g, 3.8 mmoles) is suspended in a mixture of dioxane (60 mL) and water (10 mL). Sodium chloride (0.445 g, 4.93 mmoles) and sulphamic acid (2.09 g, 21.6 mmoles) are added and the mixture is stirred at room temperature for 1 hour. The mixture is then diluted with water (100 mL) and extracted with AcOEt (200 mL). The organic layer is dried over Na2SO4 and the solvent is evaporated to yield 0.701 g of raw product which is employed in the next step without further purification.

Provenance & Evidence