Sodium Chloride → 3-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid

HRID 2427862Notes

Reaction equation

HRID 2427862 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH:9]=[O:10])[CH2:3][CH2:2]1.S(=O)(=O)([OH:20])N.[Cl-].[Na+]>C(O)(=O)C.O>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:16])[F:17])[C:9]([OH:20])=[O:10])[CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 5234Sodium ChlorideHCID 5987Sulfamic AcidHCID 189736983-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzaldehyde

Product 1

HCID 23940063-(Cyclopropylmethoxy)-4-(difluoromethoxy)benzoic Acid

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×

Procedure

3-cyclopropylmethoxy-4-difluoromethoxybenzaldehyde (12 g, 50 mmol) and sulfamic acid (7.3 g, 75 mmol) are dissolved in glacial acetic acid (50 mL) and a solution of sodium chloride (8.2 g, 75 mmol) in water (15 mL) is added. The reaction mixture is stirred at room temperature for 1 hour, then water (300 ml) is added to obtain the precipitation of the desired product that is filtered and dried at 40° C. under vacuum (12 g).

Workup

  1. customto obtain
  2. customthe precipitation of the desired product that
  3. filtrationis filtered
  4. customdried at 40° C. under vacuum (12 g)

Sources & evidence

ORD record
ord-de336744fefd4010827404302e21e4ea
Source dataset
uspto-grants-2011_06
Patent number
US07968724B2

Reaction notes

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