HCID 59161724, compound → HCID 59161732, compound

Participants

Reaction Steps

A solution of 2-[2,6-bis-(4-trifluoromethyl-phenyl)-pyridin-4-yl]-4-methyl-pent-4-enoic acid methyl ester (280 mg, 0.57 mmol), Pd/C (10%, 30 mg) in methanol (10 mL) was hydrogenated for 4 h. The mixture was filtered through Celite, washed with methanol, and evaporated. The residue was dissolved in CH2Cl2, filtered and evaporated to give the product as a white solid (260 mg, 92%). 1H NMR (300 MHz, CDCl3) δ 8.24 (d, J=8.29 Hz, 4H), 7.76 (d, J=8.29 Hz, 4H), 7.73 (s, 2H), 3.82 (t, J=7.72 Hz, 1H), 3.72 (s, 3H), 2.11 (dt, J=7.72, 13.94 Hz, 1H), 1.76 (dt, J=6.92, 13.66 Hz, 1H), 1.49-1.62 (m, 1H), 0.97 (d, J=6.40 Hz, 6H). MS m/e 496.2 (M+H).

Provenance & Evidence