Hydrochloric Acid → HCID 11947985, compound

Participants

Reaction Steps

To 60.8 ml (0.0735 mol) of diisobutylaluminium hydride in toluene (20 wt % solution) at 0° C. under argon atmosphere 10.8 g (0.0354 mol) of 4′-bromomethylbiphenyl-2-carboxylic acid methyl ester is added dropwise in a period of 30 minutes. Stirring is continued for 2 hours at the temperature between 0° C. and −5° C. Thereafter 300 ml of 1 M hydrochloric acid and 100 ml of toluene are added under stirring, layers are separated and organic layer washed 3 times with 150 ml of water. After drying with MgSO4 and evaporating under reduced pressure, 9.28 g of white crystalline powder is isolated.

Provenance & Evidence