Dimethylacetamide → HCID 11947987, compound

Participants

Reaction Steps

To a mixture of 1.098 g (3.6 mmol) of 2-n-propyl-4-methyl-6-(1′-methylbenzimidazol-2-yl)benzimidazole, 0.41 g of potassium terc-butylate (3.65 mmol) and 15 ml of N,N-dimethylacetamide, a solution of 1 g (3.6 mmol) of 4′-bromomethyl-2-hydroxymethylbiphenyl (II) in 10 ml of N,N-dimethylacetamide is added dropwise at room temperature in 30 minutes. Reaction mixture is stirred at room temperature overnight and subsequently evaporated under reduced pressure to produce 2.69 g of oily residue. Raw product is purified on chromatographic column (silica gel, dichloromethane-methanol 9:1) to yield 1.51 g of pure product in a form of brown oil.

Provenance & Evidence