Potassium Permanganate → HCID 9956095, compound

HRID 2427903Notes

Reaction equation

HRID 2427903 reaction equation
[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:22][OH:23])=[CH:12][CH:11]=2)[C:7]2[CH:24]=[C:25]([C:29]3[N:30]=[CH:31][N:32]([CH3:34])[CH:33]=3)[CH:26]=[C:27]([CH3:28])[C:6]=2[N:5]=1)[CH2:2][CH3:3].[Mn]([O-])(=O)(=O)=[O:36].[K+]>[OH-].[Na+]>[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([C:22]([OH:36])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:7]2[CH:24]=[C:25]([C:29]3[N:30]=[CH:31][N:32]([CH3:34])[CH:33]=3)[CH:26]=[C:27]([CH3:28])[C:6]=2[N:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 516875Potassium PermanganateHCID 11947987HCID 11947987, compound

Product 1

HCID 9956095HCID 9956095, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a suspension of 4′-[(2-n-propyl-4-methyl-6-(1-methylimidazol-4-yl)-benzimidazol-1-yl)methyl]-2-hydroxymethylbiphenyl (0.2 g, 0.4 mmol) in 7 ml of 4 N sodium hydroxide solution, 0.252 g of potassium permanganate (1.5 mmol) is added. Reaction mixture is then stirred overnight at room temperature and finally quenched with 30 ml of saturated solution of Na2CO3. The obtained mixture is filtered, clear filtrate acidified with acetic acid to pH 4-5 and precipitated solid isolated and dried. Yield: 0.08 g.

Workup

  1. additionis added
  2. customReaction mixture
  3. customfinally quenched with 30 ml of saturated solution of Na2CO3
  4. filtrationThe obtained mixture is filtered
  5. customprecipitated solid
  6. customisolated
  7. customdried

Sources & evidence

ORD record
ord-79d1885051d2407fb112f9415e0dddc1
Source dataset
uspto-grants-2011_06
Patent number
US07968727B2

Reaction notes

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