2-Bromo-5-chloro-1-(methoxymethoxymethyl)benzene → 5-Chloro-1-(3-Fluorophenyl)-1,3-dihydrobenzo[c][1,2]oxaborole

HRID 2427937Notes

Reaction equation

HRID 2427937 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([B:8]2[O:12][CH2:11][CH2:10]O2)[CH:5]=[CH:6][CH:7]=1.Br[C:14]1C=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=1COCOC>>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]2[B:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)[O:12][CH2:11][C:10]=2[CH:18]=1

Participants

3

Reactant 2

HCID 590246772-Bromo-5-chloro-1-(methoxymethoxymethyl)benzeneHCID 667047452-(3-Fluorophenyl)-1,3,2-dioxaborolane

Product 1

HCID 112073555-Chloro-1-(3-Fluorophenyl)-1,3-dihydrobenzo[c][1,2]oxaborole

Procedure

This was prepared as per the procedure in Example 11, from 2-(3-fluorophenyl)-[1,3,2]-dioxaborolane and 1-bromo-4-chloro-2-((methoxymethoxy)methyl)benzene to afford white crystalline product.

Workup

  1. customto afford white crystalline product

Sources & evidence

ORD record
ord-9fa3bb7a9587477791752e9f81197e68
Source dataset
uspto-grants-2011_06
Patent number
US07968752B2

Reaction notes

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