HRID2428032

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)c1nc(-c2cccc(O)c2)nc(Nc2cccc3c2ccn3S(=O)(=O)c2ccccc2)c1N

HCID57474791

未命名化合物

结构：NC(=O)c1nc(-c2cccc(O)c2)nc(Nc2cccc3c2ccn3S(=O)(=O)c2ccccc2)c1N

HCID57474792

未命名化合物

PRODUCTS

生成物

结构：NC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2-c1cccc2[nH]ccc12

HCID57474795

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21705897

未命名化合物

PROCEDURE

实验过程

5-Amino-2-(3-hydroxyphenyl)-6-(1-(phenylsulfonyl)-1H-indol-4-ylamino)pyrimidine-4-carboxamide. Methyl 5-amino-2-(3-hydroxyphenyl)-6-(1-(phenylsulfonyl)-1H-indol-4-ylamino)pyrimidine-4-carboxylate (0.1 g, 0.19 mmol) was stirred in 7N NH3/MeOH (20 mL) at 55° C. for 24 h. LCMS shows only the desired product. The mixture was concentrated to afford the title compound, 50 mg, 0.1 mmol, 50%. MS (ESI) m/z 501.5[M+1]+.