huagongshe.com
HRID2428042

反应详情

EQUATION

反应方程式

HRID 2428042 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2C1CCN(C(=O)OC(C)(C)C)CC1
HCID57474836

未命名化合物

结构：CCOC(=O)c1nc(-c2cccc(O)c2)nc(NC2CCN(C(=O)OC(C)(C)C)CC2)c1N
HCID57474837

未命名化合物

PRODUCTS

生成物

1
结构：NC(=O)c1nc(-c2cccc(O)c2)nc2c1[nH]c(=O)n2C1CCNCC1
HCID57474838

未命名化合物

收率 19%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Ethyl 9-(1-(tert-butoxycarbonyl)piperidin-4-yl)-2-(3-hydroxyphenyl)-8-oxo-8,9-dihydro-7H-purine-6-carboxylate. Ethyl 5-amino-6-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)-2-(3-hydroxyphenyl)pyrimidine-4-carboxylate (0.120 g, 0.260 mmol) and 1,1′-1,1′-carbonyldiimidazole (0.425 g, 2.62 mmol) in dichloromethane (10 mL) were reacted according to General Procedure F and purified via biotage chromatography (0-70% EtOAc in hexanes) to afford the title compound (0.050 g, 19%). MS (ESI) m/z 484.3 [M+1]+.

WORKUP

后处理

  1. custompurified via biotage chromatography (0-70% EtOAc in hexanes)