Hydrochloric Acid → HCID 11692572, compound

Participants

Reaction Steps

{7-[2,6-Bis-(4-hydroxymethyl-phenylethynyl)-pyridine-4-ylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester (70 mg; 0.12 mmol) was dissolved in a mixture of THF and ethanol (1:2) (30 ml) and 1N sodium hydroxide (1 ml) was added. The reaction mixture was stirred for about 16 h and 1N aqueous hydrogen chloride (2 ml), water (10 ml) and ethyl acetate (20 ml) were added. The organic phase was separated from the aqueous phase and the aqueous phase was extracted with ethyl acetate (10 ml). The pooled organic phases were washed with water (10 ml), dried and evaporated to dryness to give {7-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-indan-4-yloxy}-acetic acid. Yield: 64 mg LC-MS (system 1): Rt: 2.09; Mw: 562.5.

Provenance & Evidence