Dimethylformamide → HCID 67266527, compound

Participants

Reaction Steps

7-(2,6-Dibromo-pyridin-4-ylsulfanyl)-2-methyl-phenoxy}-acetic acid methyl ester (0.3 g; 0.67 mmol, prepared as described in example 6), cupper iodide (3.8 mg; 0.02 mmol), 4-ethynylbenzylalcohol (266 mg; 2.01 mmol) and bis(triphenylphosphine) palladium (II) chloride (18.8 mg; 0.027 mmol) were added to a dry reaction flask under an atmosphere of nitrogen. Triethylamine (2 ml) and DMF (2 ml) was added and the reaction mixture was reacted at 70° C. for 10 min in a microwave oven. The reaction mixture was purified by preparative HPLC (method B) to give {4-[2,6-bis-(4-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester. Yield: 260 mg; 70%.

Provenance & Evidence