Hydrochloric Acid → HCID 11533898, compound

Participants

Reaction Steps

{4-[2,6-Bis-(2-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl-phenoxy}-acetic acid methyl ester (51 mg; 0.090 mmol) was dissolved in a mixture of THF and ethanol (2:1) (10 ml) and 1N sodium hydroxide (0.5 ml) was added. The reaction mixture was stirred for about 1 h and 1N aqueous hydrogen chloride (3 ml), water (10 ml) and ethyl acetate (20 ml) was added. The organic phase was separated from the aqueous phase and the aqueous phase was extracted with ethyl acetate (10 ml). The pooled organic phases were washed with water (10 ml), dried and evaporated to dryness. The crude product was purified by prep. HPLC to give {4-[2,6-bis-(2-hydroxymethyl-phenylethynyl)-pyridin-4-ylsulfanyl]-2-methyl-phenoxy}-acetic acid. Yield: 23 mg.

Provenance & Evidence